Genetic Hereditary Cancers Screening

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 APC, ATM, AXIN2, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, CTNNA1, DICER1, EPCAM, FH, GREM1, HOXB13, KIT, MBD4, MEN1, MLH1, MSH2, MSH3, MSH6, MUTYH, NF1, NTHL1, PALB2, PDGFRA, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SDHA, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, TP53, TSC1, TSC2, VHL 

 The Genetic  Hereditary  Cancers Screening delves into genes that are predominantly linked to cancers occurring in adulthood without specific syndromes, affecting organs such as the breast, ovary, uterus, prostate, and gastrointestinal tract. Due to the genetic diversity of these cancers, relying solely on physical characteristics to pinpoint the exact cause is often inadequate. This screening, with its comprehensive approach, enables the efficient examination of multiple genes implicated by a single clinical sign. It should be noted that some genes tested may also be related to other distinct conditions not covered by this screening. Genetic analysis of these genes can be instrumental in confirming clinical diagnoses, forecasting the likely course of the disease, detecting symptoms early, guiding family planning and genetic counseling, or identifying eligibility for clinical studies. This test is tailored to detect inherited germline mutations and is not designed to identify somatic mutations in tumors.

1. APC-associated polyposis conditions

2. Ataxia telangiectasia (A-T)

3. Hereditary breast and gynecologic cancers

4. Oligodontia-colorectal cancer syndrome

5. Juvenile polyposis syndrome (JPS)

6. Hereditary breast and ovarian cancer syndrome (HBOC)

7. BAP1 tumor predisposition syndrome

8. Hereditary diffuse gastric cancer syndrome

9. CDK4-related cutaneous melanoma

10. Melanoma-pancreatic cancer syndrome and melanoma-neural system tumor syndrome

11. DICER1-related pleuropulmonary blastoma familial tumor predisposition syndrome

12. Lynch syndrome

13. Constitutional mismatch repair deficiency (CMMR-D)

14. FH tumor predisposition syndrome

15. Hereditary mixed polyposis syndrome

16. HOXB13-related predisposition to prostate cancer

17. Familial GIST, familial mastocytosis

18. Multiple endocrine neoplasia type 1

19. MSH3-associated polyposis

20. MUTYH-associated polyposis (MAP)

21. MBD4-associated neoplasia syndrome (MANS)

22. NF1-related conditions

23. NTHL1-associated polyposis

24. GIST-plus syndrome

25. Polymerase proofreading–associated polyposis (PPAP)

26. PTEN hamartoma tumor syndrome

27. Hereditary paraganglioma-pheochromocytoma syndrome

28. Small cell carcinoma of the ovary, hypercalcemic type

29. Peutz-Jeghers syndrome

30. Li-Fraumeni syndrome

31. Tuberous sclerosis complex

32. von Hippel-Lindau syndrome